New Chelsea signings David Luiz and Marcos Alonso are unlikely to start against Swansea, according to head coach Antonio Conte.
Kurt Zouma is not yet ready to return from a knee injury.
Swansea's record signing Borja Baston could feature for the first time after overcoming a thigh injury.
Fellow new arrival Alfie Mawson is also in the squad, while Welsh full-back Neil Taylor returns from a post-Euro 2016 break.
MOTD COMMENTATOR'S NOTES
Steve Bower: "Antonio Conte has already won one all-Italian affair away from home. If, like at Walter Mazzarri's Watford, his team can beat Swansea, he'll become only the fourth Chelsea manager to win his first four league games in charge.
"That would be an extremely satisfactory start to his campaign following a few frustrations in the transfer market, and all eyes will be on the return of David Luiz at the Liberty Stadium.
"Francesco Guidolin looks to avoid three consecutive defeats as Swansea begin the task of upsetting the odds ahead of a daunting run of home fixtures, with Manchester City and Liverpool to follow this one."
WHAT THE MANAGERS SAY
Swansea City head coach Francesco Guidolin on Antonio Conte: "He played with Juventus for 13 years and I managed Vicenza, Udinese and Bologna teams against him. Every year I met him and he almost always won because Juventus had the best squad in Italy, and Serie A was the most important league in that period.
"His career as a player was good and now he has a very good career as manager. He is one of the most important managers in Europe."
Chelsea head coach Antonio Conte: "We have bought David Luiz because we need a centre-back. In this squad, there were Cahill and Terry, and sometimes we adapt Branislav Ivanovic in this role. But we needed centre-backs so, for that reason, we bought him.
"I know David Luiz has played in midfield before but, in my mind now, that is not an idea for us. I think this squad can play 3-4-3, not 3-5-2 like the national team in Italy and Juventus but, because of the characteristics of the players, we can play 3-4-3."
Swansea have lost both games since their opening-day win at Burnley and they barely had a sniff against Leicester. Things will not be any easier for them against Chelsea.
The Blues have won three out of three so far and I don't see that sequence stopping against the Swans.
- Swansea's 1-0 win in this fixture last season was their first in the Premier League against Chelsea (D3, L6).
- The Swans have never won consecutive league games against the Blues.
- Chelsea's 5-0 win at the Liberty Stadium in January 2015 is Swansea's heaviest top-flight home defeat.
- The Swans have conceded more goals (21) against Chelsea than any other Premier League side.
- Swansea have lost their last two league matches – they have yet to lose three successive league games under Francesco Guidolin.
- After failing to score in 11 Premier League games last season, Leroy Fer has scored in two of his three outings this season.
- Antonio Conte could become the fourth Blues manager to win his opening four Premier League matches, joining Jose Mourinho, Guus Hiddink and Carlo Ancelotti.
- Chelsea won their first four league games in all four of their title-winning seasons: 2004-05, 2005-06, 2009-10 and 2014-15.
- Diego Costa has scored five Premier League goals against Swansea, more than he has managed against any other side.
- Eden Hazard has scored six goals in his last eight league games, having failed to score in his previous 29.
- Antonio Conte was unbeaten as a manager against Francesco Guidolin in their Serie A meetings (W6, D1).