Jose Mourinho's injury crisis is mounting, with Marouane Fellaini a doubt for Manchester United's home clash with Arsenal next weekend.
Fellaini suffered a calf injury during United's 3-1 victory over Swansea but headed out to join the Belgium international team.
However, the midfielder was swiftly ruled out of the friendly against Holland on Wednesday evening and the clash against Estonia on Sunday.
Ordinarily, the Belgian team keep their players with them if the injury is thought to be minor but Fellaini was sent home to Manchester.
The 28-year-old now faces a race against the clock to make the Arsenal game, with Mourinho already without Antonio Valencia and Eric Bailly.
Doubts persist over Luke Shaw's fitness and, as exclusively revealed by Sportsmail on Friday, Chris Smalling will be out for a month with a broken toe.
Across Manchester, Vincent Kompany was also ruled out of Belgium's clash with Estonia in Brussels.
The City captain pulled out of the friendly with Holland minutes before kick-off and manager Roberto Martinez has vowed not to gamble with the fitness of the 30-year-old, who has made just four appearances this season.
'Vincent had discomfort in his groin area,' said Martinez. 'He didn't train on Friday and I am not going to take him into consideration for Sunday.
'It is nothing new. We all know Vincent is so eager to help the group at club and international level but at the moment the only thing that matters is getting him back to full fitness.